Domino's Ultimate Pepperoni Pizza, X-Large 16" Hand Tossed Nutrition Facts
One serving of Domino's Ultimate Pepperoni Pizza, X-Large 16" Hand Tossed (1 slice (1/8 pizza, 165 g)) has 480 calories, 20g of protein, 45g of carbohydrates (43g net carbs), 23g of fat and 1,110mg of sodium.
About 17% of its calories come from protein, 39% from carbs and 44% from fat.
How it compares with other specialty pizzas (per slice)
Among 44 items in Specialty Pizzas (per slice), it ranks #42 for fewest calories and #5 for most protein. Showing the closest items by calories.
Related Domino's guides
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- The Lowest-Calorie Meals at Domino's
- Domino's Keto and Low-Carb Guide
- Domino's Low-Sodium Guide
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Nutrition Facts
Serving: 1 slice (1/8 pizza, 165 g)
% Daily Value*
- Total Fat 23g
- 29%
- Saturated Fat 10g
- 50%
- Trans Fat 0.5g
- Cholesterol 55mg
- 18%
- Sodium 1,110mg
- 48%
- Total Carbohydrate 45g
- 16%
- Dietary Fiber 2g
- 7%
- Total Sugars 4g
- Protein 20g
- 40%
* Percent Daily Values are based on a 2,000 calorie diet. Figures are estimates from published restaurant data; actual portions vary by location.
Source: Domino's Nutrition Guide, US (August 2026), checked August 2026.